Prospective Instruments joined forces with Prof. Dr. Katharina Zimmermann and M.Sc. Stella Gaenger working on the N2B-patch (EU grant agreement No. 721098) project. This ground breaking project will develop a proof of concept for an intranasal nose-to-brain (N2B) drug delivery of therapeutic antibodies for multiple sclerosis (MS) treatment. Because the antibodies will be applied on the direct transport route from the nasal cavity to the brain they can bypass the blood-brain barrier which would mean a big advantage compared to the current routes of application.
Learn more about the project: https://www.n2b-patch.eu/
On Youtube Prospective Instruments published a sneak preview of a stitched image of a DAPI-stained mouse head (sagittal plane) made with their single-photon setup (16x, 0.8 NA, FOV 23 x 10 mm) - 432 nm (blue) kindly provided by Stella Gaenger. There you can clearly see the nasal cavities where the antibodies are applied.
Please follow this link to watch the video: https://youtu.be/_6MaOdVwLUo
The paper to this project - and of course further pictures - will be published in June. Something to look forward to!
Paper to the nose-to-brain (N2B) patch project published: Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory MucosaRead more
Prospective has a brandnew mesoSPIM light sheet setup.Read more